Azetidinone derivatives as .beta.-lactamase inhibitors
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United States of America Patent
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Nov 30, 1999
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N/A
app pub date -
Aug 29, 1997
filing date -
Aug 29, 1997
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Expired
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Abstract
New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted 'anti' (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial .beta.-lactamases. These compounds can be used in combination with .beta.-lactam antibiotics to increase the effectiveness of the .beta.-lactam antibiotics in fighting infection caused by .beta.-lactamase producing bacteria.
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