Reagents, methods and kits for detecting trichloroethylene and perchloroethylene

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United States of America Patent

PATENT NO 5994145
SERIAL NO

08652643

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Abstract

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Reagents, immunoassay methods, and kits for detecting the presence or amount of trichloroethylene or perchloroethylene in a sample. Reagents include antibodies, immunogens for preparing antibodies, and assay conjugates. The immunogens elicit high affinity antibodies to trichloroethylene. The antibodies have minimal crossreactivity to other halogenated and aromatic hydrocarbons. The assay conjugates provide for sufficient binding of the antibody to the conjugate with maximum inhibition of that binding by free trichloroethylene and perchloroethylene in the sample. The reagents are useful in immunoassays to detect trichloroethylene and perchloroethylene, especially in environmental samples. Kits contain antibodies specific for trichloroethylene and perchloroethylene and assay conjugates.

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Patent Owner(s)

Patent OwnerAddress
EMD CHEMICALS INC480 S DEMOCRAT ROAD GIBBSTOWN NJ 08027

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hudak, Robert T Landenberg, PA 2 34
Kozakiewicz, Cynthia A New Castle, DE 1 8
Onisk, Dale V Bear, DE 5 23
Stave, James W Elkton, MD 14 229

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