Process for the preparation of 4-amino-.DELTA.4-3-ketosteroids via 4-nitro-.DELTA.4-3-ketosteroids
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United States of America Patent
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Nov 23, 1999
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N/A
app pub date -
Feb 24, 1999
filing date -
May 2, 1994
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Expired
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Abstract
The present invention provides 4-nitro-.DELTA..sup.4 -3-ketosteroids, their use as steroid C.sub.17-20 lyase and 5.alpha.-reductase inhibitors and to a novel process for preparing a compound of the formula: ##STR1## comprising sequentially: a) reacting a starting compound of the formula ##STR2## with an effective amount of a strong base at an elevated or suitable temperature for a time sufficient to create the corresponding thermodynamic dienolate, followed by addition of a neutral nitrating agent to produce the 4-nitrosteroid; and then; b) reacting the 4-nitrosteroid with a suitable reducing agent.
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