Antibodies with reduced net positive charge
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United States of America Patent
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Nov 23, 1999
Grant Date -
N/A
app pub date -
Jan 10, 1997
filing date -
Dec 18, 1996
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Abstract
Modified antibodies which have been by chemical conjugation with agents reactive with free amino groups are disclosed. Among the chemical agents disclosed for use in connection with the invention are heterobifunctional reagents and biotin. The use of these modified antibodies in the diagnosis and therapy of cancer and other mammalian disease is also disclosed. Diagnostic uses include immunoscintography. The modified antibodies may be further conjugated with labels or biologically active molecules for use in diagnosis and therapy. The modified antibodies may also be formulated into pharmaceutical compositions for these purposes.
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