Polyethylene oxides having saccharide residue at one end and different functional group at another end
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United States of America Patent
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Oct 26, 1999
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N/A
app pub date -
Dec 18, 1997
filing date -
Apr 14, 1995
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Abstract
This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl, X denotes a single bond or --CH.sub.2 CH--, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000. This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.
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