Stimulus-inducible protein kinase complex and methods of use therefor
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United States of America Patent
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Oct 26, 1999
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app pub date -
Aug 26, 1996
filing date -
Aug 26, 1996
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Abstract
Compositions and methods are provided for treating NF-.kappa.B-related conditions. In particular, the invention provides a stimulus-inducible I.kappa.B.alpha. kinase complex, and components and variants thereof. I.kappa.B.alpha. kinase complex may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the NF-.kappa.B cascade. I.kappa.B.alpha. kinase complex, components thereof and/or such agents may also be used for the treatment of diseases associated with NF-.kappa.B activation.
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