N- methyl piperazine compounds having dopamine receptor affinity
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United States of America Patent
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Oct 19, 1999
Issued Date -
N/A
app pub date -
Oct 9, 1997
filing date -
Dec 12, 1994
priority date (Note) -
Expired
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Abstract
Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein X.sub.1 is selected from CH.sub.2, NH, O and S; X.sub.2 -- is selected from CH=, CH.sub.2 --, and N=; R.sub.1 to R.sub.8 are each independently selected from H, C.sub.1-4 alkyl, halo, cyano, nitro and halo-substituted C.sub.1-4 alkyl and acid addition salts, solvates and hydrates thereof. Their use as ligands for dopamine receptor identification and in a drug screening program, and as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia, is also described.
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