Liposomal-polyene preliposomal powder and method for its preparation
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United States of America Patent
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Oct 12, 1999
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N/A
app pub date -
Nov 26, 1997
filing date -
Jan 14, 1991
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Expired
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Abstract
A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.
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