In vivo binding pair pretargeting
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United States of America Patent
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Oct 12, 1999
Issued Date -
N/A
app pub date -
Jun 5, 1995
filing date -
Mar 4, 1992
priority date (Note) -
Expired
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Abstract
A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog. Preferably, the affinity component is thermo-stabilized.
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