Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
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United States of America Patent
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Oct 5, 1999
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May 12, 1997
filing date -
Dec 10, 1993
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Abstract
A method of lowering plasma cholesterol level in a patient with hypercholesterolemia, by administration of a compound of formula (1) ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group; Z is a thio, oxy or methylene group; A is a C.sub.1 -C.sub.4 alkylene group; and R.sub.5 is a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or napthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C.sub.1 -C.sub.6 alkyl.
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