Urinary assay for measuring bone resorption
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United States of America Patent
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Oct 5, 1999
Issued Date -
N/A
app pub date -
Dec 11, 1998
filing date -
Nov 6, 1987
priority date (Note) -
Expired
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Abstract
Urinary assay for measuring bone resorption, by contacting an unhydrolyzed urine sample with an antibody that binds to free lysyl pyridinoline cross-links, detecting any binding of the antibody in the body fluid sample, and correlating the detected binding to bone resorption in vivo. The free lysyl pyridinoline cross-links are preferably measured as a ratio to the creatinine content in order to provide a urinary index of bone resorption independent of urine volume.
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