Metabolic effects of certain glutathione analogs
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United States of America Patent
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Sep 21, 1999
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Jul 3, 1996
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Apr 3, 1992
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Abstract
Compounds of the formula ##STR1## and the esters, amides, amide/esters and salts thereof, wherein YCO is .gamma.-glu or .beta.-asp; G* is phenylglycine or glycine; Z is CH.sub.2, O or S; and X is a hydrocarbon radical selected from C.sub.6 -C.sub.8 alkyl or selected aromatic groups are useful in modulating hematopoiesis in bone marrow, mitigating the bone-marrow-destructive effects of a chemotherapeutic agent, and in potentiating the toxicity of chemotherapeutic agents.
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