Immunogenic hybrid protein OprF-OprI derived from Pseudomonas aeruginosa membrane proteins
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United States of America Patent
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Sep 21, 1999
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N/A
app pub date -
Dec 14, 1995
filing date -
Dec 16, 1994
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Abstract
The present invention relates to a hybrid protein comprising the Pseudomonas aeruginosa outer membrane protein I (OprI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF), as well as to monoclonal or polyclonal antibodies against this hybrid protein. Both, the hybrid protein and the antibodies directed to the hybrid protein confer protection against an infection by Pseudomonas aeruginosa to laboratory animals or man.
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