Method for separating unmodified hemoglobin from cross-linked hemoglobin

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United States of America Patent

PATENT NO 5952470
SERIAL NO

08477916

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Abstract

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A method for separating unmodified hemoglobin from cross-linked hemoglobin in a hemoglobin solution. The method involves contacting the hemoglobin solution with a least one dissociating agent to form a dissociation solution wherein unmodified tetrameric hemoglobin is dissociated to form hemoglobin dimers. The hemoglobin dimers are then separated from the dissociation solution, while retaining the cross-linked hemoglobin in the dissociation solution.

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Patent Owner(s)

Patent OwnerAddress
HEMOGLOBIN OXYGEN THERAPEUTICS LLC674 SOUDER ROAD SOUDERTON PA 18964

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gawryl, Maria S Charlestown, MA 21 297
Houtchens, Robert A Milford, MA 23 309
Laccetti, Anthony J North Andover, MA 16 245
Light, William R Natick, MA 27 381

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