Assay for inhibitors of a 24 kD cytoplasmic protease which activates DNA fragmentation in apoptosis
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United States of America Patent
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Sep 14, 1999
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N/A
app pub date -
Mar 26, 1997
filing date -
Jun 10, 1994
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Expired
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Abstract
A method is disclosed for assaying for inhibitors of a 24 kDa cytoplasmic protease associated with apoptosis. The protease has a defined amino acid composition, activity against the elastase-like substrate MAAVP, and induces DNA fragmentation associated with apoptosis in isolated U937 cell target nuclei.
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