Thrombin and collagen procoagulant and process for making the same
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United States of America Patent
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Sep 14, 1999
Issued Date -
N/A
app pub date -
Feb 27, 1998
filing date -
May 25, 1993
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Abstract
A procoagulant designed to effect hemostasis at a puncture site in a patient's vasculature without the aid of manual compression is comprised of lyoplilized thrombin that is reconstituted with a buffered diluent and collagen that is mixed with the reconstituted thrombin to produce a viscous mixture. The buffered diluent is preferably of sodium phosphate and water. The procoagulant is essentially isotonic and has a pH in the range of 5-10. The method of making the procoagulant is comprised of the steps of reconstituting the lyophilized thrombin with the buffered diluent and then, mixing the reconstituted thrombin with collagen to both reduce the size of the particles of the collagen and form a fluid mixture.
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