Paclitaxel synthesis from precursor compounds and methods of producing the same
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United States of America Patent
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Sep 7, 1999
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N/A
app pub date -
Jun 7, 1995
filing date -
Feb 5, 1993
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Expired
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Abstract
An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process incudes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with variable A-ring side chain structures. A rapid and highly efficient esterification of O-protected isoserine and 3-phenylisoserine acids having N-benzyoloxycarbonyl groups to the C-13 hydroxyl of 7-O-protected baccatin III is followed by a deprotection-acylation sequence to make taxol, celphalomanninne and various analogs, including photoaffinity labeling candidates.
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