Methoxyethoxy oligonucleotides for modulation of protein kinase C expression
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United States of America Patent
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Sep 7, 1999
Issued Date -
N/A
app pub date -
Feb 14, 1996
filing date -
Mar 16, 1992
priority date (Note) -
Expired
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Abstract
Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.
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