Reverse two-hybrid system employing post-translation signal modulation
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United States of America Patent
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Sep 7, 1999
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N/A
app pub date -
Aug 4, 1997
filing date -
Aug 5, 1996
priority date (Note) -
Expired
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Abstract
The invention relates to modified two-hybrid systems, in particular a reverse two-hybrid system which employs as a reporter a gene encoding a modifying agent such as an enzyme, and a signal agent which is modified by the enzyme usually by being broken down, such that in the event of an inhibition of binding of the two hybrid proteins a detectable signal is produced. The system is particularly useful for drug screening.
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