Gene therapy for effector cell regulation

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United States of America Patent

PATENT NO 5935568
SERIAL NO

08580806

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a nucleic acid-based therapeutic composition to treat an animal with disease by controlling the activity of effector cells, including T cells, macrophages, monocytes and/or natural killer cells, in the animal. Therapeutic compositions of the present invention include superantigen-encoding nucleic acid molecules, either in the presence or absence of a cytokine-encoding nucleic acid molecule and/or chemokine-encoding nucleic acid molecules, depending upon the disease being treated. The present invention also relates to an adjuvant for use with nucleic acid-based vaccines. Adjuvant compositions of the present invention include an immunogen combined with superantigen-encoding nucleic acid molecules, either in the presence or absence of a cytokine-encoding nucleic acid molecule and/or chemokine-encoding nucleic acid molecules.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORY MEDICINE1400 JACKSON STREET DENVER CO 80206

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dow, Steve W Denver, CO 3 81
Elmslie, Robyn E Denver, CO 9 230
Potter, Terence A Denver, CO 2 7

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