Asymmetric synthesis of benzoxazinones
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United States of America Patent
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Aug 3, 1999
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app pub date -
Apr 11, 1997
filing date -
Dec 16, 1996
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Abstract
The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
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