Molecular presenting system
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United States of America Patent
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Aug 3, 1999
Grant Date -
N/A
app pub date -
Mar 31, 1997
filing date -
Aug 8, 1994
priority date (Note) -
Expired
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Abstract
The invention refers to a molecular presentation system in which viral proteins are foreseen as carriers for heterologous amino acid sequences. Hereby, the viral protein is derived from small insect viruses, primarily from Flock House Virus (FHV), with a known 3-dimensional structure and amino acid sequence, whereby heterologous amino acid sequences, for example epitopes, are inserted in the outwardly directed loops of the viral capsid protein. Moreover, the expression of the FHV capsid protein in insect cells can produce mature virus like particles (VLP) through a recombinant baculovirus.
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