Compositions and methods for modulating cellular NF-.kappa.B activation

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United States of America Patent

PATENT NO 5932425
SERIAL NO

08802322

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compositions and methods for modulating the activation of nuclear factor .kappa.B (NF-.kappa.B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I.kappa.B.alpha. and/or I.kappa.B.beta.. Such compositions may be used for treating diseases associated with NF-.kappa.B activation. Modulating agents include peptides that comprise a recognition domain for E3 ubiquitin ligase.

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Patent Owner(s)

Patent OwnerAddress
SIGNAL PHARMACEUTICALS INC4550 TOWNE CENTRE COURT SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alkalay, Irit Jerusalem, IL 6 19
Ben-Neriah, Yinon Zion, IL 17 24
Ciechanover, Aaron Haifa, IL 12 20
Manning, Anthony San Diego, CA 16 42
Mercurio, Frank San Diego, CA 83 822
Yaron, Avraham Jerusalem, IL 6 18

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