Structure-based designed herbicide resistant products
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United States of America Patent
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Jul 27, 1999
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app pub date -
May 31, 1995
filing date -
Apr 20, 1995
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Abstract
Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbicides. The invention encompasses isolated DNAs encoding such variants, vectors that include the DNAs, and methods for producing the variant polypeptides and herbicide resistant plants containing specific AHAS gene mutations. Methods for weed control in crops are also provided.
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