Iontophoresis device for the transcutaneous delivery of an active principle such as an anionic oligosaccharide
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United States of America Patent
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Jul 27, 1999
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N/A
app pub date -
Sep 29, 1997
filing date -
Jan 24, 1995
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Abstract
A device comprising a reversible negative electrode in contact with a reservoir element containing an electrolyte which contains an active principle such as an anionic oligosaccharide, particularly a pentasaccharide, in at least partially ionised form, a positive electrode alone or in combination with an electrolyte-containing receptacle, and an electrical signal generator connectable to both electrodes. The generator is arranged to apply electrical signals between the electrodes, which signals have an average voltage such that the average current density generated between the electrodes is 0.05-0.25 mA/cm.sup.2. The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm.sup.2. The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm.sup.2 and per mAh of current through 1 cm.sup.2 of the electrode.
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