Aspergillus genus showing resistance to cerulenin and L-methionine analogue and a process for preparing mevinolinic acid therefrom

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United States of America Patent

PATENT NO 5925551
SERIAL NO

08961455

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Abstract

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The present invention relates to a novel mutant of Aspergillus terreus which shows a resistance to both cerulenin and L-methionine analogue, and a process for preparing mevinolinic acid which comprises aerobic culture of the mutant strain and recovery of mevinolinic acid. The mutant of the present invention provides a remarkably high productivity of mevinolinic acid while reducing the production of byproducts such as mevinolinic acid analogues, when compared with a wild type Aspergillus terreus isolated from soil environment in Korea, and it successfully produce mevinolinic acid by employing monosaccharides such as glucose and galactose, unlike the mother strain.

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Patent Owner(s)

Patent OwnerAddress
CHONG KUN DANG CORPORATION410 SHINDORIM-DONG GURO-KU SEOUL 152-070

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Byoung-Tack Seoul, KR 1 1
Hong, Chung-Il New York, NY 4 30
Kim, Byoung-Kook Kyunggi-Do, KR 2 1
Kim, Jung-Woo Seoul, KR 104 852
Kim, Kyung-Hwan Seoul, KR 57 444
Park, Jang-Woo Kyunggi-Do, KR 2 2

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