Clostridium difficle toxins as mucosal adjuvants

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United States of America Patent

PATENT NO 5919463
SERIAL NO

08543708

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Abstract

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The invention features methods and compositions for inducing protective and/or therapeutic immune responses to an antigen in a mammal. In these methods, an antigen is administered to the mammal with a toxin of a Clostridium (e.g., C. difficile), or a fragment or derivative thereof having adjuvant activity.

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Patent Owner(s)

Patent OwnerAddress
ACAMBIS INC38 SIDNEY STREET CAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lei, Wende Cambridge, MA 9 299
Lyerly, David M Radford, VA 20 306
Monath, Thomas P Harvard, MA 41 591
Moncrief, James S Christiansburg, VA 1 32
Thomas, Jr William D Winchester, MA 7 206
Torres-Lopez, Francisco Javier San Clemente, MX 1 32
Zhang, Zhenxi Cambridge, MA 13 299

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