2,4-pentadienoic acid derivatives having retinoid-like biological activity
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United States of America Patent
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Jun 29, 1999
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app pub date -
Aug 20, 1997
filing date -
Jun 6, 1995
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Abstract
Enantiomerically substantially pure compounds of the formula ##STR1## where R is H or lower alkyl of 1 to 6 carbons, or pharmaceutically acceptable salts thereof have retinoid-like biological activity. The enantimerically pure or substantially pure compound of the above formula where R is H, or a pharmaceutically acceptable salt thereof, is highly specific agonist of RXR retinoid receptors in preference over RAR receptors.
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