Synthetic peptide derivatives and the salts thereof
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United States of America Patent
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Jun 1, 1999
Grant Date -
N/A
app pub date -
Jun 30, 1995
filing date -
Jul 4, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides synthetic peptide derivatives represented by the formula P.sup.1 -R.sup.1 -P.sup.2 wherein P.sup.1 is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P.sup.2 is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R.sup.1 denotes a linker with a property that does not interfere with the activity of the each peptide P.sup.1 and P.sup.2 to bind N-terminal end of the peptides P.sup.1 and P.sup.2. The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.
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