Process for the preparation of disodium benzyloxycarbonyl-L-aspartate from fumaric acid
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United States of America Patent
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May 11, 1999
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N/A
app pub date -
Sep 19, 1997
filing date -
Sep 20, 1996
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Abstract
A process for the preparation of disodium Z-L-aspartate from fumaric acid, in which a) fumaric acid is reacted with ammonia in an inert diluent in the presence of aspartase or aspartase-producing microorganisms to give ammonium L-aspartate then b) the ammonium L-aspartate-containing solution is treated with sodium hydroxide, forming, depending on the amount of sodium hydroxide used, the mono- or disodium L-aspartate or a mixture thereof, and c) the eliminated ammonia is returned to a fumaric acid suspension, which is used as starting solution for further enzymatic reactions, and then d) the residual mono and/or disodium L-aspartate-containing solution is reacted with benzyloxycarbonyl chloride at a pH of between 9 and 14, with the simultaneous addition of sodium hydroxide, to form disodium Z-L-aspartate.
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