Transgenic mouse expressing C-100 app
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United States of America Patent
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Apr 13, 1999
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N/A
app pub date -
Feb 26, 1996
filing date -
Feb 26, 1996
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Expired
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Abstract
A transgenic mouse whose genome comprises a DNA sequence encoding the carboxy-terminal 100 amino acids of the human .beta.-amyloid precursor protein C-100 APP) inserted into exon I of the neurofilament gene such that all or part of exon I has been deleted is disclosed. Expression of the nucleic acid sequence is under the control of neurofilament L-gene regulatory region. The mouse as a result of the expression exhibits a brain morphology of an increased amyloid accumulation, and increase in reactive astrocytes, an increased microglial activation and a decreased number of neurons, and also exhibits spatial memory impairment.
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