Methods and compositions for impairing multiplication of HIV-1
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United States of America Patent
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Apr 6, 1999
Grant Date -
N/A
app pub date -
Jul 11, 1997
filing date -
Jul 11, 1997
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Abstract
A composition is provided which contains a non-naturally occurring peptide or polypeptide comprising at least two or more, and preferably all four amino acid sequences -Asp-Pro-Arg-Leu-Glu-Pro- SEQ ID NO: 6; -Asp-Pro-Lys-Leu-Glu-Pro- SEQ ID NO: 7; -Asp-Pro-Ser-Leu-Glu-Pro- SEQ ID NO: 8; and -Asp-Pro-Asn-Leu-Glu-Pro- SEQ ID NO: 9. This composition, including a number of additional optional peptides or polypeptides, and in a variety of forms, demonstrates a biological activity of inducing antibodies that react with most HIV-1 Tat proteins and impairing the multiplication of HIV-1. Also provided are synthetic genes encoding these peptides, recombinant viruses and commensal bacterium carrying these genes, transfected host cells, and polyclonal or other types of antibodies produced by immunizing other mammals with these aforementioned compositions. Methods for making and using such compositions to lower the viral level of HIV-1 are described.
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