Nucleic acids encoding HIV-1 trans-dominant mutants and their use to abrogate HIV-1 viral replication
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United States of America Patent
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Mar 30, 1999
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app pub date -
Jan 4, 1994
filing date -
Jan 4, 1993
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Abstract
The human immunodeficiency virus type 1 (HIV-1) contains the canonical genes gag, pol, env, tat, rev, vif, vpr, vpu, and nef. The tat gene encodes an early regulatory protein that transactivates viral gene expression through interactions with a trans-activation responsive region (TAR). The instant invention is directed toward nucleic acids encoding site-directed trans-dominant Tat variants with reduced trans-activation capabilities as compared to wild-type. These variants are also capable of inhibiting wild-type Tat activity when present in the appropriate molar concentrations. Tat mutants were constructed by introducing single amino acid substitutions at positions 38, 40, 41, 45, and 47 of the wild-type coding region. A further aspect of the invention is directed toward expression cassettes containing these nucleic acids and methods of producing them. These reagents should prove useful in the identification of anti-viral compounds.
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