Method to increase the stability of nanocapsules during storage thereof
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United States of America Patent
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Mar 23, 1999
Issued Date -
N/A
app pub date -
Jul 24, 1997
filing date -
Apr 20, 1993
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Abstract
Methods of increasing storage stability of lipidic nucleus nanocapsules comprising adding a monosaccharide cryoprotective agent into the aqueous dispersion of the nanocapsules while maintaining gentle stirring until the same dissolves totally. Afterwards, freezing said dispersion thus obtained at a temperature of not less than -40.degree. C. for about 2 to 4 hours, and the eliminating the water by heating progressively to a temperature of about 35.degree. C. at reduced pressure, whereby a stable lyophilized product is obtained. The obtained product can be conveniently reconstituted by adding water or a more complex aqueous solution thereto. The nanocapsules have use in medicine, pharmacy, cosmetics, chemical industry, agriculture, and veterinary science.
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