Arginine mimic derivatives as enzyme inhibitors
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United States of America Patent
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Mar 16, 1999
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app pub date -
Jun 7, 1995
filing date -
Jun 17, 1994
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Abstract
The present invention provides peptide aldehydes having an azetidinyl, prolyl or pipecolyl group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis are also described.
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