Process for preparing cyclosporin A
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United States of America Patent
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Feb 23, 1999
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app pub date -
Jun 16, 1997
filing date -
Oct 13, 1994
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Abstract
A process for the isolation of cyclosporin A comprising the steps of: adding a lower alkanol solvent to a culture fluid of a mutant of Tolypocladium inflatum to form a mixture, filtering the mixture to form an extract, transferring the extract to methylene chloride as a solvent therefor, and column chromatographing the resultant product on silica gel.
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