Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocompatible matrix core

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United States of America Patent

PATENT NO 5874099
SERIAL NO

08449837

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Abstract

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A method of forming an implantable and retrievable immunoisolatory vehicles is disclosed, the method comprising the steps of first forming a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells capable of providing a biologically active product or metabolic or immunologic function, said cells being dispersed in a biocompatible hydrogel or extracellular matrix, and then forming around the core a surrounding external biocompatible thermoplastic or hydrogel jacket free of said cells projecting externally thereof, said jacket having molecular weight cutoff permitting passage of molecules to and from the core through said jacket to provide said biologically active product or function.

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Patent Owner(s)

Patent OwnerAddress
NEUROTECH S ABATIMENT GENOPOLE-INDUSTRIES 4 RUE PIERRE FONTAINE 91000 EVRY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aebischer, Patrick Lutry, CH 56 5283
Christenson, Lisa New Haven, CT 11 1005
Dionne, Keith E Rehoboth, MA 42 3669
Emerich, Dwaine F Providence, RI 34 1926
Gentile, Frank T Warwich, RI 31 2044
Hegre, Orion D Green Valley, AZ 16 1194
Hoffman, Diane Cambridge, MA 11 1005
Lacy, Paul E Webster Grove, MO 14 1212
Lysaght, Michael J E. Greenwich, RI 24 1398
Sanberg, Paul R Spring Hill, FL 64 1715
Scharp, David W St. Louis, MO 16 1194
Vasoohcellos, Alfred V Cranston, RI 1 38

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