Azole compounds with antimycotic activity for human and veterinary use
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United States of America Patent
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Feb 9, 1999
Grant Date -
N/A
app pub date -
Feb 25, 1997
filing date -
Feb 28, 1996
priority date (Note) -
Expired
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Abstract
Compounds of formula ##STR1## wherein R.sub.1 is chloro, fluoro, bromo or trifluoromethyl; R.sub.2 is hydrogen, chloro, fluoro, bromo or trifluoromethyl; Z is CH or N; R.sub.3, R.sub.4 and R.sub.5, which are the same or different, are hydrogen or C.sub.1 -C.sub.4 alkyl, with the proviso that R.sub.4 is different from R.sub.5 when R.sub.3 is hydrogen; X is O, S, SO or S0.sub.2 ; R.sub.6 is a C.sub.1 -C.sub.5 polyfluoroalkyl group containing at least two fluorine atoms and optionally other halogen atoms selected from the group consisting of chloro and bromo; processes for their preparation and pharmaceutical compositions containing them are described. The compounds of formula II-A are endowed with a marked wide range antimycotic acitivity.
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