Hybrid proteins with modified activity
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United States of America Patent
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Feb 9, 1999
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app pub date -
Jun 25, 1997
filing date -
Nov 13, 1995
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Abstract
Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.
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