Methods and apparatus for monitoring the growth of microorganisms in liquid culture
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United States of America Patent
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Jan 26, 1999
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N/A
app pub date -
Jun 2, 1993
filing date -
Aug 2, 1991
priority date (Note) -
Expired
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Abstract
A method of monitoring the growth of microorganisms in liquid culture involving the detection of pressure change in a gas-tight container such as a blood culture bottle incorporating a flexible diaphragm (septum) by detecting displacement of the septum, is characterised by the position or conformation of the diaphragm being repeatedly sensed using a distance-measuring means, such as a laser, preferably capable of detecting a variation in the position or conformation of the diaphragm to an accuracy of 200.mu. or better, with a portion of the container adjacent the diaphragm conveniently being used as a reference to detect any relative positional or conformational change of the diaphragm. Preferably the laser repeatedly scans a plurality of containers mounted in a holder such as a flat bed or a carousel.
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