Transcription factor DP-3 and isoforms thereof
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United States of America Patent
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Jan 12, 1999
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N/A
app pub date -
Sep 30, 1996
filing date -
May 15, 1996
priority date (Note) -
Expired
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Abstract
The invention provides polypeptides of transcription factor DP-3 which exists in four isoforms produced by alternative splicing of mRNA, nucleic acid encoding the polypeptides and the use of such nucleic acid and polypeptides in assays. Two isoforms of DP-3 contain a region, designated the E region, which is a nuclear localization signal and is involved in a further level of regulation of DP-3 and its ability to bind to E2F-1 and regulate the cell cycle.
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