Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as .alpha..sub.1 -adrenergic receptor antagonists

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United States of America Patent

PATENT NO 5859014
SERIAL NO

08658774

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Abstract

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Compounds of Formula I: ##STR1## where R.sup.5 is a group selected from Formulae (a), (b), (c) and (d): ##STR2## and the pharmaceutically acceptable salts and N-oxides thereof, are .alpha..sub.1 -adrenergic receptor antagonists useful for the treatment of diseases involving directly or indirectly an obstruction of the lower urinary tract, such as benign prostatic hyperplasia.

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Patent Owner(s)

Patent OwnerAddress
SYNTEX (U S A ) INC3401 HILLVIEW AVENUE PATENT LAW AND LICENSING DEPARTMENT MAILSTOP A2-200 PALO ALTO CA 94304

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bantle, Gary W Calgary, CA 2 19
Elworthy, Todd R Palo Alto, CA 9 159
Guzman, Angel Colonia Jardines en la Montana, MX 9 53
Jaime-Figueroa, Saul Fremont, CA 41 539
Lopez-Tapia, Francisco J Fremont, CA 1 19
Morgans, Jr David J Los Altos, CA 21 301
Perez-Medrano, Arturo Mexico City, MX 38 328
Pfister, Jurg R Los Altos, CA 36 266
Sjogren, Eric B Mountain View, CA 39 434
Talamas, Francisco X San Carlos, CA 10 168

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