Retroviral vector hybrids and the use thereof for gene transfer
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United States of America Patent
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Jan 12, 1999
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N/A
app pub date -
Mar 7, 1997
filing date -
Sep 8, 1994
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Expired
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Abstract
Replication-defective retroviral vector hybrids which are characterized in that they contain a) the U5 region and/or tRNA primer binding site of MESV as the U5 region and/or tRNA primer binding site in the leader region and b) the U3 and R regions from a Friend murine leukaemia virus (F-MuLV) as the U3 and R regions in the 3'-LTR and which are particularly suitable for an effective gene transfer in haematopoietic stem cells.
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