Monoclonal antibodies specific for the PSA-ACT complex

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United States of America Patent

PATENT NO 5856182
SERIAL NO

08749525

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Monoclonal antibodies have been developed which specifically bind the PSA-ACT complex without significant cross-reactivity with PSA, ACT or CG-ACT. The antibodies were generated using a unique immunogen comprising a PSA-ACT complex having bound to monoclonal antibodies against PSA and monoclonal antibodies against ACT. It is theorized that the antibodies against PSA and ACT block immunodominant sites on the PSA-ACT complex. The antibodies generated against the unique immunogen specifically bind the PSA-ACT complex, but have no significant cross-reactivity with either PSA or ACT. The monoclonal antibodies of the present invention can be used in immunoassays to specifically detect PSA-ACT in a sample.

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Patent Owner(s)

Patent OwnerAddress
BECKMAN INSTRUMENTS INC485 POTRERO AVENUE SUNNYVALE CA 94086

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kuus-Reichel, Kristine San Diego, CA 4 36
Linton, Harry Jay Encinitas, CA 1 2
Payne, Janice K San Diego, CA 1 2
Wang, Tang J Poway, CA 3 10

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