Monoclonal antibodies which neutralize HIV-1 infection

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United States of America Patent

PATENT NO 5854400
SERIAL NO

07950571

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Murine monoclonal antibodies and related products such as antibody fragments, immunotoxins, human and humanized antibodies are disclosed, all of which bind to the gp120 protein on the envelope of HIV-1. These antibodies and related products neutralize HIV-1. They inhibit the infection of T cells, and also inhibit syncytium formation. Further, the antibodies are preferably group-specific and neutralize various strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment of AIDS and ARC, the prevention of HIV-1 infection, as well as a diagnostic application, in that they can be used for assaying of unknown fluid samples for HIV-1.

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Patent Owner(s)

Patent OwnerAddress
TANOX INC10301 STELLA LINK HOUSTON TX 77025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Nancy T Houston, TX 24 245
Chang, Tse Wen Houston, TX 25 540
Fung, Michael S C Houston, TX 22 381
Sun, Bill N C Wellfort Bellaire, TX 20 326
Sun, Cecily R Y Wellfort Bellaire, TX 37 733

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