Transgenic mice as a model for metabolic bone diseases
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United States of America Patent
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Dec 15, 1998
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N/A
app pub date -
Apr 25, 1995
filing date -
Apr 27, 1994
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Expired
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Abstract
Transgenic mice carrying a recombinant DNA construct comprising the gene encoding diphtheria toxin A chain operably linked to a osteocalcin promoter. The transgenic mice can be used as a model for metabolic bone diseases since they have decreased bone mass associated with a marked reduction in the number of osteoblasts.
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