O-sulfated gangliosides and lyso-ganglioside derivatives
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United States of America Patent
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Dec 15, 1998
Grant Date -
N/A
app pub date -
Jan 31, 1996
filing date -
Mar 4, 1993
priority date (Note) -
Expired
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Abstract
Disclosed are derivatives of gangliosides and of N-acyl-N-lyso-gangliosides, of N'-acyl-N'-lyso-gangliosides and N,N'-di-or poly-acyl-N,N'-di-lyso-gangliosides, in which at least one of the hydroxyl groups in the saccharide, sialic or ceramide residues is esterified with sulfuric acid, functional derivatives thereof, and their salts with either inorganic or organic bases and the acid addition salts, except persulfated derivatives at the hydroxyl, sialic and ceramide groups of the GM.sub.1, GD.sub.1a, GD.sub.1b and GT.sub.1b gangliosides. Such compounds have antineurotoxic and neurotogenic activity and may therefore be used in pharmaceutical preparations. Also a marked modulating effect on the expression of the CD.sub.4 molecule in immune system cells has been shown.
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