Gene therapy using stromal cells
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United States of America Patent
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Dec 15, 1998
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app pub date -
Mar 22, 1995
filing date -
Feb 2, 1989
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Abstract
A method of causing production and secretion into the bloodsream of a human patient of a biologically active enzyme for which the human patient suffers a deficiency; the method involves introducing into the human patient donor bone marrow stromal cells which have been transfected with a gene encoding the enzyme, so that the introduced cells can adhere to a bone cavity surface of the patient and produce and secrete the active enzyme.
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