Methods for the diagnosis of peripheral nerve damage
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United States of America Patent
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Dec 1, 1998
Issued Date -
N/A
app pub date -
Jun 7, 1995
filing date -
Nov 30, 1990
priority date (Note) -
Expired
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Abstract
Methods of diagnosing peripheral nerve damage, including diagnosing and monitoring chronic back and cervical pain are disclosed. The methods involve subjecting a body fluid sample from a patient suspected of having chronic lumbar or cervical pain and peripheral nerve damage to two-dimensional electrophoresis or an immunoassay and measuring relative amounts of protein or proteins which increase or decrease in concentration as compared to a standard control. A preferred method employs an Apo-E variant as a marker of peripheral nerve damage. Also disclosed are kits for use with the diagnostic methods.
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