Nucleic acids encoding the .gamma.-MSH receptor MC3-R

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United States of America Patent

PATENT NO 5837521
SERIAL NO

08044812

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Abstract

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The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular melanocortin receptor, termed MC3-R, isolated as a complementary DNA copy of mRNA corresponding to the gene for this receptor in rats. Also provided is a eukaryotic recombinant expression construct capable of expressing a mammalian melanocortin receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize a mammalian melanocortin receptor. The invention also provides methods for screening in vitro agonists and antagonists of such a melanocortin receptor using preparations of receptor protein from such cultures of eukaryotic cells transformed with a recombinant expression construct.

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Patent OwnerAddress
OREGON STATE OF3181 S W SAM JACKSON PK RD PORTLAND OR 92701

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cone, Roger D Oregon City, OR 22 149
Mountjoy, Kathleen G Portland, OR 12 54
Robbins, Linda S Portland, OR 3 9
Roselli-Rehfuss, Linda Portland, OR 3 9

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